Mørch RH, et al. – Author's purpose is to assess if plasma levels of inflammatory markers are persistently altered in severe mental disorders with psychotic symptoms or correlated with state characteristics in a longitudinal study. Persistently increased soluble tumor necrosis factor receptor 1 (sTNF–R1) and interleukin–1 receptor antagonist (IL–1Ra) after one year in patients with severe mental disorders primarily reflecting data from the schizophrenia group might suggest that inflammation is a trait phenomenon, and not only the outcome of stress–related mechanisms related to acute episodes.