Reddy VY, Neuzil P, de Potter T, et al. - For patients with high stroke risk and atrial fibrillation for whom who oral anticoagulants (OACs) are unsuitable, a new permanent coil filter directly placed into both common carotid arteries (CCAs) was designed to capture emboli > 1.4 mm in diameter in order to prevent stroke. Researchers, via this multicenter, nonrandomized, first-in-human clinical Carotid Artery Implant for Trapping Upstream Emboli for Preventing Stroke in Atrial Fibrillation Patients trial, investigated if bilateral CCA filter placement is feasible and safe. Patients with atrial fibrillation, CHA2DS2-VASc ≥ 2, not suitable for OAC, CCA size 4.8 to 9.8 mm, and no carotid stenosis > 30% were eligible for inclusion. The procedure yielded a success rate of 92% (23 of 25 patients); unilateral deployment was reported in one patient. No device/procedure-related major adverse events were identified, and 5 of 25 (20%) reported minor puncture site hematomas/edema. Overall, findings revealed the technical feasibility as well as safety of permanent carotid filter placement for stroke prevention.