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Periventricular hemorrhagic infarction in very preterm infants: Characteristic sonographic findings and association with neurodevelopmental outcome at age 2 years

The Journal of Pediatrics Nov 14, 2019

Cizmeci MN, de Vries LS, Ly LG, et al. - In very preterm infants born in 2008-2013, researchers conducted this retrospective multicenter observational cohort study to analyze the sonographic features of periventricular hemorrhagic infarction (PVHI) and their correlation with mortality and neurodevelopmental disability. Participants in the study were 160 infants with median gestational age of 26.6 weeks. PVHI was mostly unilateral, linked to an ipsilateral grade III intraventricular hemorrhage, and located in the parietal lobe. In the neonatal period, 64 infants with PVHI died. Data reported that the cerebral palsy rate was 42%. An independent risk factor for poorer cognitive and motor outcomes was associated posthemorrhagic ventricular dilation. In very preterm infants, increasing PVHI size and severity score were predictive of less optimal gross motor outcome and death.
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