Hanly JG, Li Q, Su L, et al. - Researchers determined the frequency, clinical features, relationships and outcomes in different types of peripheral nervous system (PNS) disease in a multi-ethnic/racial, prospective SLE inception cohort. Study participants were assessed annually for 19 neuropsychiatric (NP) events including seven types of PNS disease. Of 1,827 patients (mean ± SD age was 35.1±13.3 years) with SLE, 88.8% were female, 48.8% Caucasian. In patients with prior history of neuropathy, older age at SLE diagnosis, higher SLEDAI-2 K scores, and peripheral neuropathy vs other neuropathies, multivariate Cox regressions suggested a longer resolution. Neuropathy has been linked to significantly lower SF-36 physical and mental component summary scores compared with patients without NP events. Most neuropathies have been resolved or improved over time by physician assessment and this has been associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy. PNS disease is an important element of total NPSLE and has a major adverse effect on health-related quality of life. For most patients, the result is favorable, but the authors observed several factors connected with longer resolution time.