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Peripheral nerve field stimulation for chronic back pain: Therapy outcome predictive factors

Pain Practice Mar 29, 2020

van Gorp EJ, Eldabe S, Slavin KV, et al. - Researchers assessed patients with chronic back pain, with mainly failed back surgery syndrome, in this exploratory univariate and multivariate (random forest) analyses performed separately on 2 randomized controlled trials and a registry in order to determine variables that influence pain reduction following peripheral nerve field stimulation (PNFS) and to recognize a potential responder profile. PNFS success in patients with back pain may be predicted in correlation with the following variables: patient and pain characteristics (age, time since onset of pain and spinal surgery, pain medication history, position and size of pain area, pain severity, mixed nociceptive/neuropathic pain, health‐related quality of life, depression, functional disability, and leg pain status), implant procedure variables (the number and position of leads, paresthesia coverage, and amount of pain relief during the trial), and programming (number of programs, cathodes, and anodes; pulse rate; pulse width; and percentage of device usage). However, these results are informative only and should be interpreted with caution. 

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