Bourrier M, et al. - Given a more common occurrence of peripheral artery disease (PAD) in chronic kidney disease (CKD) patients as well as its link with lower-limb complications and death, researchers performed this retrospective cohort analysis to compare the prevalence of PAD in and outside the setting of kidney disease, as well as to explore the impact of PAD on the risk for adverse health consequences, particularly lower-limb complications, cardiovascular events, and survival. Participants were 453,573 adult inhabitants of Manitoba, who had undergone at least 1 serum creatinine evaluation between 2007 and 2014. The PAD prevalence was estimated to be 4.5%, and PAD patients exhibited older age, more chance of being male, and a higher burden of comorbid conditions, including diabetes and CKD. Overall, patients with CKD glomerular filtration rate categories 3 to 5 and G5D vs those with estimated glomerular filtration rate ≥ 60 mL/min/1.73 m² more commonly developed PAD. PAD frequently resulted in lower-limb complications. There is an urgent necessity for medical interventions and care pathways especially meant to slow or avert the development of lower-limb complications in this population.