Martin YN, et al. - Among adult surgical patients who underwent procedures with general, regional, or combined general/regional anesthesia, researchers assessed the effects of Suboxone (SL-BUP; a sublingual formulation of buprenorphine-naloxone) on perioperative pain management. The patients had received SL-BUP within 30 days before procedures. During the procedure, in the post-anesthesia care unit (PACU), and during the 24 h after PACU discharge, opioid use was recorded. They compared opioid use in cases with continued SL-BUP until the day of surgery to cases with preoperative discontinuation of SL-BUP. Based on the findings, physicians are strictly recommended to be prepared to deliver large doses of opioids during the early postoperative period in patients with SL-BUP, irrespective of the type of anesthesia used. Patients who perioperatively stopped SL-BUP vs those who continued SL-BUP showed no difference in opioid demands.