Christensen D, Moschetti W, Brown M, et al. - To prevent surgical site infection and periprosthetic joint infection (PJI) after total joint arthroplasty (TJA), use of perioperative antibiotic prophylaxis is made. Owing to a national shortage of cefazolin, patients are provided a single preoperative prophylactic antibiotic dose and no 24-hour postoperative antibiotic prophylaxis for primary TJA. In this study, the efficacy of single dose antibiotic use vs 24-hour dosing of prophylactic antibiotics was examined in the prevention of acute PJI and short-term complications following primary TJA. Researchers retrospectively reviewed 3,317 patients undergoing primary TJA; of these, 554 patients had received a single-dose of preoperative antibiotic prophylaxis because of the antibiotic shortage and 2,763 patients had received post-TJA 24-hour antibiotic prophylaxis before the shortage occurred. Outcomes revealed no increased risk of acute PJI or short-term complications after TJA in correlation with single-dose prophylactic antibiotics. They support that in routine primary TJA patients, administration of a single antibiotic dose may be safely considered.