Leira Y, et al. - In this study, authors assessed 120 cases with lacunar infarct (LI) vs 120 healthy controls to define the association of periodontitis with raised circulating levels of systemic inflammation and endothelial dysfunction biomarkers in LI cases. They found an independent relationship between increased levels of interleukin (IL)-6, pentraxin (PTX) 3, soluble fragment of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK), and amyloid-beta (Aβ) peptides (Aβ_1-40) and periodontitis in subjects with LI. They also noticed a positive correlation of periodontal inflamed surface area (PISA) with IL-6, PTX3, sTWEAK, and Aβ_1-40 in patients with poor outcome.