Shah JS, Vaughan DA, Leung A, et al. - In this retrospective cohort study, researchers desired to know how a shift in clinical practice along with laboratory changes has affected singleton perinatal outcomes after autologous in vitro fertilization (IVF) cycles. From August 1, 1995, to October 31, 2019, singleton live births resulting from all IVF cycles (n = 14,424). The entire cohort comprised 9,280 fresh and 5,144 frozen IVF cycles. Both groups had identical maternal age, parity, BMI, neonatal sex, and GA at delivery. Over a 24-year period, there has been a decrease in birth weight for the entire cohort of IVF cycles due to the gradual evolution of clinical and IVF laboratory practices. Concurrently, notable practice changes have resulted in improved IVF outcomes, including lower rates of large for GA newborns and preterm birth before 32 weeks for the entire cohort of IVF cycles.