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Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects

Annals of Epidemiology Nov 07, 2017

Kerr SM, et al. - Researchers used the Slone Epidemiology Center Birth Defects Study (1998 to 2015) to assess the impact of folic acid on the relationship between maternal fever in the periconceptional period (28 days before and after the last menstrual period) and neural tube defects (NTDs). Findings suggested that the maternal periconceptional fever was associated with an increased risk for NTDs. In addition, they gained evidence suggesting attenuation of this association for mothers who reported consuming folic acid at recommended levels in the periconceptional period.
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