Yozawa S, et al. – This study investigated the impact of a peri–articular injection of tranexamic acid (TXA) on blood loss following a total knee arthroplasty (TKA) in patients who received an autologous blood transfusion. As a result of treating patients with peri–articular TXA injection, attenuation in postoperative bleeding and decline in hemoglobin and hematocrit, with no increment in the risk of venous thrombosis or the necessity of an allogeneic blood transfusion were observed.