Kortekaas KE, Solleveld‐Westerink N, Tessier‐Cloutier B, et al. - In this research, the performance and interobserver variability of this pattern‐based p53‐immunohistochemistry (IHC) approach were ascertained. Via Cohen’s kappa, agreement was estimated. Via a consensus meeting, all disagreements regarding p53‐IHC patterns were resolved. Researchers ascertained the presence of pathogenic TP53 variants by next‐generation sequencing after DNA isolation. They estimated sensitivity, specificity, and accuracy of p53‐IHC as a surrogate marker for TP53 mutation status. The outcomes of this study exhibit that pattern‐based p53‐IHC classification is highly reproducible amongst experienced gynecologic pathologists and accurately reflects TP53 mutations in vulvar squamous cell carcinoma (VSCC). This method to p53‐IHC interpretation provide guidance and offers necessary clarity for resolving the proposed prognostic relevance of final p53‐IHC class within HPV‐independent VSCC.