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Performance of serum creatinine and kidney injury biomarkers for diagnosing histologic acute tubular injury

American Journal of Kidney Diseases Aug 28, 2017

Moledina DG, et al. – Cross–sectional analysis from multicenter prospective cohort was carried out to analyze the performance of serum creatinine (Scr) and kidney injury biomarkers for diagnosing histologic acute tubular injury. For diagnosing acute tubular injury in hospitalized deceased donors, a lack of accuracy was noticed in concentrations of Scr and kidney injury biomarkers. As compared to Scr concentration, urinary neutrophil gelatinase–associated lipocalin [NGAL] concentration had slightly higher discrimination for acute tubular injury. However, overall area under the receiver operating characteristic curve (AUROC) of urinary NGAL concentration was still modest.
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