Jacobs A, et al. - In this secondary analysis of the randomized controlled Early versus Late Parenteral Nutrition in the Pediatric Intensive Care Unit trial, researchers evaluated and compared the performance of two frequently used PICU mortality prediction scores, viz, the Pediatric Index of Mortality 3 and the Pediatric Risk of Mortality III scores, for the prediction of PICU and 90-day mortality. They compared the discrimination (area under the receiver operating characteristic curve) and the calibration of these two scores. This investigation was carried out in 3 PICUs within academic hospitals in Belgium, the Netherlands, and Canada and included 1,428 critically ill patients aged 0–17 years. Findings revealed that the performance of the Pediatric Index of Mortality 3 vs Pediatric Risk of Mortality III was better in calibration for predicting PICU and 90-day mortality and was not impacted by intervention or PICU quality of care. Thus, Pediatric Index of Mortality 3 appeared a better choice for use in clinical trials with 90-day mortality as primary outcome.