Moser O, Sternad C, Eckstein ML, et al. - In this study, intermittently scanned continuous glucose monitoring (isCGM) systems well-performed relative to reference blood glucose measurements. A diminished performance of isCGM was evident with rate of change in glucose for both increasing and decreasing glucose levels; a lower accuracy was seen during high rates of glucose change.

• According to previous analyses, the rate of glucose change influences the accuracy measures of isCGM systems.

• Via this pooled analysis, 12 studies comprising 311 participants (15,837 paired measurements) were analyzed to evaluate isCGM system accuracy based on the rate of change in sensor glucose.

• Through Median Absolute Relative Difference (MedARD), Parkes Error Grid and Bland-Altman plot, isCGM performance was assessed.

• The overall MedARD was reported to be 12.7% [5.9—23.5] and a significant difference in the MedARD was evident depending on the rate of change in glucose (p<0.001).

• There was an absolute difference of -22 mg/dL (95% Limits of Agreement (LoA) 60 mg/dL; -103 mg/dL) when glucose was quickly rising (isCGM glucose minus reference blood glucose) while a 32 mg/dL (95% LoA 116 mg/dL; -51 mg/dL) absolute difference was identified in periods of quickly declining glucose.