Gomez B, et al. - This study is subjected to investigate the role of C reactive protein (CRP), performance of prolactin (PCT), absolute neutrophil count (ANC) for ruling out paediatric invasive bacterial infection (IBI). This study compares two groups, one is 196 infants of <21 days old and other is 1331 infants of 22-90 days old. Data reported that the values improved in infants with fever ≥6 hours (aged 22–90 days), but not in those ≤21 days. The result does not show any significant role of CRP, PCT and ANC to determine IBI in febrile infants <21 days.