Lee J, et al. - In this matched case-control study using propensity score matching, researchers investigated how well a Quick Sequential Organ Function Assessment-65 (qSOFA-65) score can perform to recognize sepsis. They also compared the qSOFA-65 score vs systemic inflammatory response syndrome (SIRS) and qSOFA scores. Participants were 2,441 in total. For the qSOFA-65, qSOFA, and SIRS positive criteria for sepsis, the sensitivity and specificity scores were estimated to be 0.66 and 0.73, 0.28 and 0.97, and 0.66 and 0.55, respectively. A significantly higher AUC value was generated for predicting sepsis for qSOFA-65 positive criteria vs that of qSOFA and SIRS positive criteria. Compared with qSOFA or SIRS, the likelihood of recognizing patients with sepsis on the initial ED visit was more with the use of qSOFA-65. This may have quality improvement implications in predicting sepsis.