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Performance characteristics of pulmonary function tests for the detection of interstitial lung disease in adults with early diffuse cutaneous systemic sclerosis

Arthritis & Rheumatology Oct 07, 2020

Bernstein EJ, Jaafar S, Assassi S, et al. - This research was attempted to investigate the performance characteristics of pulmonary function tests (PFTs) for the detection of interstitial lung disease (ILD) in patients with early diffuse cutaneous systemic sclerosis (dcSSc), a population at high risk for the development of ILD. Between April 2012 and January 2019, researchers conducted a retrospective cohort study of patients enrolled in the Prospective Registry of Early Systemic Sclerosis at 11 sites in the US. Individuals were enrolled whether they had undergone spirometry and high‐resolution computed tomography (HRCT) of the chest. The performance characteristics of PFTs were estimated for the detection of ILD on HRCT. The research enrolled 212 patients, 54% of whom had radiographic ILD. It was reported that in patients with early dcSSc, PFTs alone are an inadequate screening tool for the diagnosis of ILD. The data suggest that in patients with dcSSc., HRCT should be part of the ILD screening algorithm.

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