Chen Y, Wen Y, Yu Q, et al. - In this study, the efficacy and safety of percutaneous nephrolithotomy (PCNL) and ureteroscopic lithotripsy (fURL) were analyzed in the treatment of upper urinary tract stones, providing a reference for clinical work. Researchers carried out to search PubMed, Web of Science, Embase and CNKI through Apr. 1, 2019 to distinguish eligible studies. T RevMan 5.3 and Stata 12.0 software were applied to examine data. They estimated pooled relative risks (RRs) or weighted mean difference with 95% confidence intervals (CIs) applying fixed or random-effects methods. They conducted publication bias and sensitivity analysis. Researchers enrolled four randomized controlled trials (RCTs), fifteen cohort studies including a total of 1,822 patients. The data suggested that the stones clearance rate of PCNL is higher than fURL, and the safety of fURL is higher than PCNLin the treatment of upper urinary tract stones.