Cornelis FH, et al. – This non–blinded, no–randomized trial was designed to report the safety and short–term adequacy of percutaneous image–guided cryoablation conducted as second–line therapy of venous vascular malformations (VVM) of extremities. According to the data, percutaneous cryoablation was considered as a promising alternative treatment for sclerotherapy–resistant venous malformations. Nevertheless, to enhance safety, careful patient selection and treatment planning will be mandatory.