Ho KY - In this systematic analysis, the author examines the current perceptions or beliefs of physicians or patients with respect to the safety and effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs). Out of a total of 2,822 studies retrieved from different databases, 99 met the criteria for inclusion. Overall, patients' level of awareness about NSAIDs has been found to be considerably low. Additionally, physicians must practice risk stratification to reduce the incidence of adverse events. The common perceptions were associated with gastrointestinal, cardiovascular, renal and respiratory safety, efficacy and COX-2 inhibitors.