Malone J, Reisner SL, Cooney EE, et al. - Researchers herein described self-perceived risk of HIV among transgender women who are preexposure prophylaxis (PrEP)-indicated.

• This cross-sectional analysis was performed including 1,293 transgender women.

• Using transgender women–specific criteria, PrEP indication prevalence was 47% (611), which is 155 more than those identified using the Centers for Disease Control and Prevention (CDC) criteria.

• Among PrEP-indicated individuals, PrEP use and adherence was recorded in 13% at the time of the study.

• Fifty-five percent of PrEP-indicated participants had low or no self-perceived HIV risk.

• Health care providers are required to have further guidance for prescribing PrEP to transgender women.

• Further, there is necessity for greater uptake and adherence for optimal effectiveness.