Winblad S, et al. - In 32 consecutive patients with myotonic dystrophy type 1 (DM1) and 30 healthy controls matched by sex, age and education, researchers assessed perceived fatigue, functional limitations experienced because of fatigue, and clinical associations. On the Fatigue Impact Scale (FIS), perceived fatigue was rated. According to this case-control study, higher levels of fatigue were suggested by a higher total FIS score in DM1 patients vs healthy controls. In particular, DM1 patients did not score higher than controls on the cognitive scale of the FIS, but they did on the physical and psychosocial subscales of the FIS. Overall, investigators concluded that in patients with DM1, perceived fatigue is significantly more common vs healthy controls; higher ratings of depression and muscle impairment were linked to this finding. Both depression and muscle impairment seem to contribute to fatigue in DM1.