Jan M, et al. – This study was performed to analyze safety and mid–term (12 and 24 months) clinical outcomes of per–oral endoscopic myotomy (POEM) for achalasia. In the study population POEM resulted in greater than 90% treatment success at 12 months which tends to decrease to 84% after 2 years. Mild reflux symptoms and/or mild esophagitis was evident in more than one–third of the patients.