Anterasian CM, et al. - Researchers used a pediatric outpatient population to assess the negative predictive value (NPV) of the current skin testing regimen of penicillin, benzylpenicilloyl-polylysine (the major determinant), and ampicillin. Ultimately, they intended to assess the utility of adding the minor determinant mixture to the skin testing regimen. They performed a retrospective chart review including all pediatric patients who presented to a single-center pediatric allergy/immunology outpatient clinic between January 1, 2010, and March 1, 2016, and who underwent penicillin skin testing (PST) for presumed penicillin drug allergy. They did not recommend additional testing with the minor determinant mixture in view of the high NPV of the current PST regimen. They found limited utility of PST in the low-risk, low-pretest probability outpatient pediatric population, though NPV was high. As per their observations, select patients may be able to proceed directly to oral challenge.