Popp J, Trendelenburg V, Niggemann B, et al. - In this study with a pediatric sample having pea-specific IgE ≥ 0.35 kUA/L and clinical proof of pea allergy or tolerance, researchers focused on the allergenic relevance as well as the diagnostic utility of pea 7S globulin Pis s 1, nsLTP, and 2S albumins PA1 and PA2. IgE immunoblot/inhibition was employed to assess IgE binding against pea total protein extract, recombinant (r) rPis s 1, rPA1, rPA2, and natural nsLTP. Pis s 1 was identified as a major immunodominant allergen among children having pea allergy. Experts found low evidence for sensitization to nsLTP and 2S albumins but this needs to be further validated with regard to conformational epitopes. Experts suggested that verification of recombinant Pis s 1 and associated peptides, which were exclusively identified by pea allergic children, in prospective investigations with larger study groups may afford an improved in vitro diagnosis of pea allergy.