Lee HJ, Shin DH, Lee YJ, et al. - By performing this retrospective study, researchers assessed how clinical outcome in Xp11 translocation renal cell carcinoma (TRCC) can be influenced by programmed death‐1 ligand (PD‐L1) expression and the immune microenvironment, and also evaluated the potential relevance of these as prognostic biomarkers. From 311 patients who had nephrectomy for renal cell carcinoma (RCC), FFPE specimens were taken. In TRCC, the expression of PD‐L1 and immune cells CD8, CD4, CD3, forkhead box protein 3 (FoxP3) and programmed death 1 was determined, relative to other types of RCC. Experts found higher PD‐L1 expression in TRCC vs in other types of RCC. Poor recurrence‐free survival was reported in TRCC in correlation with high PD‐L1 tumour cell expression and tumour infiltration by CD4⁺ and FoxP3⁺ immune cells.