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PD-1 and PD-L1 in locoregionally advanced nasopharyngeal carcinoma: Substudy of a randomized phase III trial

Head & Neck Apr 21, 2019

Cao C, et al. - One hundred and eight subjects were analyzed to examine the expression of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) via immunohistochemistry review in locoregionally advanced nasopharyngeal carcinoma (NPC) cases taking cisplatin, fluorouracil, and docetaxel followed by concurrent chemoradiotherapy. They identified PD-1 positive staining as an independent prognosticator for progression-free survival. An association of Epstein–Barr Virus antibody levels and PD-1 positive staining in NPC was also recorded. They did not find a correlation between the PD-L1 level and hemoglobin, lactate dehydrogenase, and high-sensitivity C-reactive protein. They also reported that high levels of PD-L1 staining were not significantly correlated with clinical outcomes.

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