Hogner A, et al. - The clinicopathologic association of PBRM1 (Polybromo-1 gene) and VHL (von Hippel-Lindau gene) expression at the mRNA and protein levels in clear cell renal cell carcinoma (ccRCC) and the roles in tumor progression were determined. A connection was shwon between reduced expression of PBRM1 and VHL and increased tumor aggressiveness. Low VHL expression can serve as a risk factor for worse patient overall survival independent ofPBRM1 expression pattern.