PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumors
Histopathology Jul 12, 2018
Toki S, et al. - The utility of PAX7 immunohistochemistry in whole-tissue sections of an expanded array of round cell malignancies with adequate molecular characterization was assessed in this analysis. For the purpose of this investigation, 30 molecularly confirmed Ewing sarcomas, one EWSR1-NFATC2 sarcoma, and 141 non-Ewing round cell tumors by a monoclonal antibody against PAX7 were stained. Researchers reported that PAX7 was a sensitive marker for Ewing sarcoma, anti-PAX7 antibody also stained several Ewing sarcoma mimics, whose spectrum was distinct from NKX2-2-positive non-Ewing entities.
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