Pricolo VE, et al. - Researchers evaluated possible differences in patient population and care delivery for squamous cell carcinoma of the anus (SCCA) between academic and community cancer programs in the US. Findings revealed existence of gender, demographic and socio-economic differences in the patient population with SCCA accessing different cancer programs in the US. They identified a high incidence of stage unknown patients, indicating ongoing challenges in the pre-treatment phase. Systemic chemotherapy and/or radiotherapy was administered to a significant percentage of stage 0 patients instead of treating with surgery alone. Variations in treatment choices, particularly the use of radiotherapy, with associated cost and toxicity risks were noted, despite comparable stage at diagnosis and comorbidity scores between Academic Cancer Programs and Community Cancer Programs. They suggested further analysis and monitoring of SCCA management in the US to improve compliance with National Comprehensive Cancer Network guidelines.