Gettelfinger JD, et al. - Researchers conducted a systematic review in order to describe the breadth and depth of patient safety/quality improvement (PS/QI) research dedicated to Otolaryngology–Head and Neck Surgery (OHNS) as well as to recognize knowledge gaps and potential areas of future study. They used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) process for prior development of the study protocol. Computerized searches led to identification of 11,570 eligible articles; of these, 738 (6.4%) met otolaryngology PS/QI inclusion criteria; 178 (24.1%) were not specific to any one subspecialty. Subspecialty foci that were most prevalent included head and neck (29.9%), pediatric otolaryngology (16.9%), and otology/neurotology (11.0%). In most OHNS PS/QI projects (32.0%), the focus was on describing complications or risk factors, followed by outcomes/quality measures (16.3%). Healthcare disparities, multidisciplinary care, and the WHO category of studies translating evidence into safer care were the knowledges gaps for future research.