Quick AM, Zvinovski F, Hudson C, et al. - In this pilot study, it was inquired how fractional CO2 laser therapy in breast cancer (BC) survivors with genitourinary syndrome of menopause (GSM) could alter their sexual function. This analysis involved 67 BC survivors, of which 59 completed treatments and 4-week follow-up; 39 took part in the 12 month follow-up. Three treatments with fractional CO2 laser were received by participants, and they were analyzed for patient-reported outcomes and adverse events at 12 months. Employing the Female Sexual Function Index (FSFI) and Female Sexual Distress Scale Revised (FSDS-R), sexual function was assessed. Findings revealed improvements in the total and individual domain scores of the FSFI and the FSDS-R following fractional CO2 laser therapy in BC survivors with GSM.