Zdenkowski N, et al. - In this planned analysis of a multi-institutional single arm longitudinal study, researchers focused on the possible differences in psychological outcomes based on treatment sequence (chemotherapy or surgery first) or tumour response in patients considering neoadjuvant systemic therapy (NAST) for operable breast cancer. The patient-reported outcome questionnaires were completed by the participants prior to and following the decision regarding NAST, between chemotherapy and surgery, and 12 months post-diagnosis. This study included 59 women. When suggested as an option by the surgeon, NAST was opted by most of the patients. More anxiety and lower satisfaction with their decision were reported by patients who preferred surgery first as compared to those who had NAST. Lack of pathological complete response did not seem to correlate with adverse psychological outcomes in patients who received NAST.