Chung KC, et al. - Through a cohort study of 338 subjects at 19 centers in the United States and Asia from August 1, 2016, to April 12, 2018, researchers contrasted long-term patient-reported and functional outcomes among subjects treated with revision amputation or replantation for digit amputations. In the replantation cohort, Disabilities of the Arm, Shoulder, and Hand (DASH), and Patient-Reported Outcomes Measurement Information System (PROMIS) scores, adjusted aggregate comparison of patient-reported outcomes (PROs) in subjects with revision amputation and replantation exposed significantly better outcomes. In subgroup analyses, DASH scores were markedly lower, symbolizing less disability and pain, and PROMIS scores higher following the replantation. in comparison to those managed with revision amputation, subjects with 3 or more digits amputated (including thumb) had significantly better PROs following the replantation. Cases who underwent replantation following 3 or more digits amputated (excluding the thumb) had higher Michigan Hand Outcomes Questionnaire scores, which did not attain statistical importance. Better 2-point discrimination was obtained by the revision amputation in the subgroup with single-finger amputation distal to the proximal interphalangeal joint. Replantation led to better 9-hole peg test times in the subgroup with 3 or more digits amputated (including thumb), better Semmes-Weinstein monofilament test in the subgroup with 3 or more digits amputated (excluding the thumb), and better 3-point pinch test in the subgroup with 2 digits amputated (excluding the thumb), in contrast to revision amputation. Therefore, replantation was suggested when technically feasible in 3 or more digits amputated and in single-finger amputation (excluding the thumb) distal to the proximal interphalangeal joint because it obtained better PROs, with long-term functional advantage. However, for its integral role in opposition, thumb replantation is still advised.