Iaccarino JM, et al. - Via this secondary analysis of data collected in the National Lung Screening Trial (NLST), researchers studied the results of each individual low-dose computed tomography (LDCT) performed in the NLST (downstream evaluation, complications, lung cancer diagnoses). The results at the test-level were then compared to outcomes calculated at the patient-level for those randomized to LDCT screening. The total LDCT scans were 75,138, of which 14.2% resulted in a diagnostic study and 1.5% an invasive procedure, with procedure-related complication and a serious complication resulted from 0.3% and 0.1% of LDCT scans, respectively. Those who had LDCT screening were 24,453, of these, 30.5% underwent a diagnostic study and 4.2% an invasive procedure. A procedure-related complication and a serious complication was reported in 0.9% and 0.3% of screened patients, respectively. For shared decision-making, significant patient-level data were extracted from the NLST that can be used as guidance. In some patients, significant variations in the risk-benefit ratio of screening could be seen, such as those with chronic obstructive pulmonary disease, in whom both risks and advantages of screening may be increased.