Ferreira RJO, Fautrel B, Saraux A, et al. - This study attempted to ascertain if the patient global assessment of disease activity (PtGA) over the first year of disease course, as part of a Boolean-based definition of remission and considered individually, had a significant association with structural progression over 3 years in patients with early arthritis. Researchers performed a prospective, observational study using ESPOIR (Étude et Suivi des Polyarthrites Indifférenciées Récentes) cohort data including a total of 520 patients. They ascertained radiographic progression as a change of ≥5 points in the total Sharp/van der Heijde score (ΔSHS) from baseline to 3 years. Via odds ratio, the predictive capacities for radiographic damage of different remission definitions were assessed. Multivariate linear regression analyses were used to investigate the association between each component of remission with ΔSHS. The findings revealed, all definitions of remission led to low structural degradation, and 4-variable remission led to less radiographic progression than PtGA near remission, but without a statistically significant difference. The data indicate that both 4-variable remission and 3-variable remission seem to be useful targets when aiming for structural nonprogression.