Nesseler N, et al. - Researchers performed this retrospective observational multicentre study on brain-injured patients requiring mechanical ventilation who survived the first 24 h in the ICU. The goal was to determine the factors related to the decision to withdraw or withhold life support (WWLS) as well as to assess the outcomes and time to death in these subjects. They reported a high proportion of deaths in relation to an end-of-life decision in this nationwide cohort of brain-injured patients. The factors that were found to have an association with the decision to WWLS were older age and several disease severity factors (presence of one nonreactive and dilated pupil, Glasgow Coma Scale less than 7, barbiturate use, acute respiratory distress syndrome and worsening lesions on computed tomography scans).