Carey RM, et al. - An exploratory analysis was performed of the correlation between patient, disease and treatment factors with overall survival in the case of esthesioneuroblastoma (ENB). Surgery followed by radiation served as the commonly practiced treatment for ENB. It exhibited a connection with the highest overall survival. Additional analyses were warranted for an appraisal of the role of adjunctive chemotherapy.

Methods

• An investigation was pursued of the NCDB for location codes corresponding to the nasal cavity and paranasal sinuses and the histology code for ENB.
• Multivariate analyses discerned the contributing factors to overall survival.

Results

• The eligible candidates comprised of 1225 patients with ENB.
• The 5-year overall survival was 76.2% (95% confidence interval [CI], 73.4-79.0%).
• Overall survival exhibited a connection with Kadish stage, grade, treatment sequence, margin status, Charlson/Deyo score, age, and gender (p < 0.05).
• Multivariate analysis illustrated that surgery followed by radiation without chemotherapy gave rise to improved all-cause mortality (odds ratio [OR], 0.61; 95% CI, 0.40-0.95), compared to surgery alone.
• Surgery with chemotherapy alone exhibited a link with increased odds of all-cause mortality (OR, 4.86; 95% CI, 2.31-10.25).
• Multivariate subanalysis for Kadish stages A and B did not reveal any variation in the survival between surgery and surgery followed by radiation.
• Nonetheless, surgery followed by chemoradiation presented with a worse overall survival (OR, 3.03; 95% CI, 1.07-8.56).
• Surgery followed by radiation reported improved overall survival compared with surgery alone (OR, 0.44; 95% CI, 0.24-0.81), for Kadish stage C.