Coughlin LN, Zhang L, Bohnert ASB, et al. - A retrospective cohort study of patients who died from stimulant-involved overdose between annual years 2012 and 2018 investigating the trends in stimulant-alone and stimulant and other substance use overdose deaths during this period. Further, patient and service use characteristics were determined across stimulant-related overdose death profiles.

• The National Death Index revealed death from stimulant-involved overdose for a total of 3,631 patients.

• Among US Veterans, a three times higher rate of deaths from stimulant-related overdose was recorded in 2018 than 2012.

• Compared with cocaine-involved overdoses, methamphetamine-involved overdoses were less frequent among older individuals and more frequent among those who lived in rural areas.

• Lower odds of a stimulant use disorder diagnosis were recorded among people who died from stimulant + opioid overdoses relative to stimulant alone deaths (cocaine: aOR = 0.55, 95% CI = 0.41–0.75, methamphetamine: aOR = 0.44, 95% CI = 0.29–0.68).