Coughlin LN, Zhang L, Bohnert ASB, et al. - Patients who died from stimulant-involved overdose between annual years 2012 and 2018 were retrospectively studied to describe trends in stimulant-alone and stimulant and other substance use overdose deaths during this period. Further, patient and service use characteristics across stimulant-related overdose death profiles were determined.

• The National Death Index led to the identification of 3,631 patients who died from stimulant-involved overdose.

• Relative to the year 2012, 2018 recorded 3.06 times higher rate of overdose death, with increases across all toxicology profiles.

• Methamphetamine-involved overdoses were less frequent among people who were older and were more frequent among those who lived in rural areas when compared with cocaine-involved overdoses.

• A stimulant use disorder diagnosis is less frequent among people who died from stimulant+opioid overdoses when compared with stimulants alone deaths (cocaine: aOR = 0.55, 95%CI:0.41-0.75, methamphetamine: aOR = 0.44, 95%CI:0.29-0.68).