Malik AO, Amin A, Kennedy K, et al. - Since there is a direct association of contrast volume, used during percutaneous coronary intervention, with contrast-associated acute kidney injury, therefore, researchers constructed a novel strategy, by using the National Cardiovascular Data Registry acute kidney injury risk model, to determine safe contrast limits by entering a contrast term into the model and utilizing it to meet specific (eg, 10%) relative risk decreases. A total of 141,133 patients at high risk for acute kidney injury were finally included. Acute kidney injury rates were 10.0% and 18.2% when the contrast thresholds derived from experts’ patient-centered model were met and when they were exceeded, respectively. The rate of contrast-associated acute kidney injury was 9.8% and 14.5%, in patients who received contrast ≤ 3 × estimated glomerular filtration rate (n = 82,318), when the contrast thresholds derived from the patient centered model were met and when they were exceeded, respectively. Overall, actionable information for providers is afforded by a novel strategy for developing personalized contrast volume thresholds, that ultimately could result in reduction of the rates of contrast-associated acute kidney injury.