Iwata S, Zhang M, Hajime M, et al. - This study was undertaken to evaluate the role of metabolic regulator rheumatoid arthritis (RA) in B cells and its relevance to the pathology of RA. In this study, peripheral blood mononuclear cells were isolated from 31 normal individuals and 86 RA patients, and the gated B cells were evaluated for mTOR phosphorylation and chemokine receptor expression. It has been reported that mTOR activation in CXCR3 ⁺ memory B cells of RA patients is correlated with disease activity, mediated through IL-6 production and RANKL expression. The outcomes also imply that TNF inhibitors mediate an impact on the relationship between CXCL10 and mTOR-activated CXCR3 ⁺ memory B cells.