Scandura G, Wagner T, Beltran L, et al. - Considering the paramount significance of the identification of pathological factors involved in metastatic disease in clinical stage (CS) 1 seminoma for identifying high-risk patients, researchers sought for the pathological predictors of metastatic disease at presentation in 332 testicular seminomas. As per the eighth edition of the American Joint Committee on Cancer Tumor-Node-Metastasis staging system, pT1a has been separated from pT1b tumors according to a 3-cm size cutoff and invasion of hilar soft tissue and epididymis are upstaged as pT2. They identified 290 (87%) tumors as CS 1; 42 (13%) as CS 2/3. Patients with CS 1 had a median age of 36 years (20-81); those with CS 2/3 had a median age of 36 years (26-63). In CS 1, the mean tumor size was 38 mm (5-95 mm); in CS 2/3, it was 54 mm (8-95 mm). The strongest predictors of metastatic disease at presentation are tumor size and epididymal invasion, supporting the AJCC TNM eighth edition. Changes in American Joint Committee on Cancer Tumor-Node-Metastasis staging eighth edition have been validated in this work but a tumor size of 4 cm is suggested as a better cutoff value.