Zhao CL, Rapkiewicz A, Maghsoodi-Deerwester M, et al. - Researchers sought to report the pathological findings in the liver of patients with COVID-19. Clinical data, including age, gender, body mass index (BMI), liver function test (alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), direct bilirubin, and total bilirubin), D-dimer, and anticoagulation treatment, were obtained from 17 autopsy cases of patients with COVID-19. Histopathologic findings were examined in postmortem hepatic tissue, immunohistochemical (IHC) staining with antibody against COVID-19 spike protein, CD68 and CD61, and electron microscopy. The characteristic findings in the liver of patients with COVID-19 include large amounts of platelet-fibrin microthrombi in the hepatic sinusoids, central vein, or portal vein as well as rare megakaryocytes also identified in sinusoids and histiocytic hyperplasia. The secondary changes in COVID-19 livers include steatosis, lobular and portal tract inflammation.