Martin JW, et al. - Authors assessed the differences in pathological features and prognostics across 4 bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients. Findings suggested that the clinicopathological features and their prognostic impact across bladder cancer subtypes differed significantly. In SCC and ADC, the prognostic significance of LVI was more evident, while in UCV, LN involvement was more prognostic. Multimodal treatment selection and clinical trial design could be guided by determining independent predictors in individual subtypes.