Bequignon E, Mangin D, Bécaud J, et al. - To better understand the mechanisms resulting in epithelial cell dysfunction in nasal polyps (NPs), researchers assessed the in vitro impacts of interleukin (IL)-6 on epithelial repair mechanisms in a wound repair model as well as on ciliary beating in primary cultures of Human Nasal Epithelial Cells. They investigated whether epithelial repair mechanisms and mucociliary clearance could be modified by IL-6 among the inflammatory cytokines implicated in NPs. In vitro, IL-6 was shown to accelerate airway wound repair, with a dose–response effect whereas experts identified no effect following other ILs-stimulation. In polyps, the up-regulation of epithelial cell proliferation was suggested to be caused by IL-6 in the case of prior epithelial damage. The possible role of IL-6 as a major cytokine in NP physiopathology was suggested.