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Partial remission in type 1 diabetes and associated factors: Analysis based on the insulin dose-adjusted HbA1c in children and adolescents from a regional diabetes centre, Auckland, New Zealand

Pediatric Diabetes Jul 02, 2019

Chiavaroli V, et al. - In children and adolescents with type 1 diabetes (T1D), partial remission (PREM) according the insulin dose-adjusted HbA1c (IDAA1c) has not been assessed for the combined ethnicity and socioeconomic status correlations, so researchers studied the prevalence and PREM predictors defined by IDAA1c. Participants in the study were 614 of 678 children (aged <15 years) with new-onset T1D (2000–2013) from a regional pediatric diabetes service (Auckland, New Zealand). The overall 3-month PREM rate was 42.4%; it was lower in MĀori/Pacific children (28.6%) and those of other ethnicities (28.8%) vs New Zealand Europeans (50.4%). Children aged 0-4.9 years (23.8%) and 10-14 years (40.9%) had lower PREM rates than children aged 5-9.9 years (57.4%). Ketoacidosis and duration of diabetes predicted lower PREM rates. Additional research on reducing diagnostic ketoacidosis rates and addressing factors linked to lower PREM rates in non-European children are important health priorities.

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