Schmidt DC, Kessel L, Pedersen KB, et al. - A systematic literature review was conducted in PubMed, EMBASE and Cochrane Library databases to assess the effectiveness of vitrectomy combined with hyaloido‐zonula‐iridectomy from an anterior or a posterior approach in patients with treatment‐resistant aqueous misdirection (chronic aqueous misdirection) by systematically reviewing existing literature in conjunction with the presentation of a case series. Vitrectomy combined with a hyaloido‐zonula‐iridectomy should be considered performed in treatment‐resistant malignant glaucoma to ensure the connection between the anterior chamber and the vitreous cavity. If the condition has long remained unresolved, extensive angle synechiae may decrease the success rate due to chronic angle closure.